The
Drying Granulator is a machine that can make material into a certain structure and shape. It is an important innovation in the technology of granulators.
Dry granulation technology can be accomplished by a flat press granulator. The traditional Chinese medicine extract with a certain relative density is spray-dried to obtain a dry extract powder, and after adding certain auxiliary materials, it is pressed into a thin sheet by a dry extrusion granulator, and then pulverized into granules. The method requires less auxiliary materials, which is beneficial to improve the stability, disintegration and dispersibility of the particles. Generally dry extract powder plus 0.5-1 times auxiliary materials can be used. However, it should also be noted that the dry extract obtained by spray drying has strong wettability. Therefore, the key to the application of this method is to find suitable excipients. The excipients must have certain adhesive properties and are not easy to absorb moisture, such as lactose, pregelatinized starch, mannitol, water-soluble acrylic resin and cellulose derivatives. Wait.
The dry granulator requires less auxiliary materials, which is beneficial to improve the stability, disintegration and dispersibility of the particles. Generally dry extract powder plus 0.5-1 times auxiliary materials can be used. However, it should also be noted that the dry extract obtained by spray drying has strong wettability. Therefore, the key to the application of this method is to find suitable excipients. The excipients must have certain adhesive properties and are not easy to absorb moisture, such as lactose, pregelatinized starch, mannitol, water-soluble acrylic resin and cellulose derivatives. Wait.
What can the dry granulation machine technology achieve?
The purpose of dry granulation is as follows:
1. Make the material into an ideal structure and shape;
2. For accurate quantification, formulation and management;
3. Reduce the dust pollution of the powder;
4. A non-segregation mixture of different types of particle systems;
5. Improve the appearance of the product;
6. Prevent agglomeration during the production of certain solid phase materials;
7. Improve the flow characteristics of the separated raw materials;
8. Increase the volumetric quality of the powder for easy storage and transportation;
9. Reduce the risk during handling of toxic and corrosive materials;
10. Control the dissolution rate of the product;
11. Adjust the void ratio and specific surface area of the finished product;
12. Improve heat transfer and help burn;
13. Adapt to different biological processes.
September 23, 2022
